PLEASE READ THE PACKAGE INSERT CAREFULLY BEFORE USE.
Keep the package insert for reference. If you have any questions that are not addressed here, please consult your physician. This drug has been individually prescribed by your physician for personal use. Under no circumstances do not administer it to others, even if they appear with the same symptoms, it may harm them. If you notice any of the side effects stated in this package please notify your doctor or pharmacist immediately.
WHAT IS CLOMIPHENE CITRATE
Clomiphene is a non-steroidal fertility medicine. It causes the pituitary gland to release hormones needed to stimulate ovulation (the release of an egg from the ovary). Clomiphene is used to cause ovulation in women with certain medical conditions (such as polycystic ovary syndrome) that prevent naturally occurring ovulation.
Clomiphene may also be used for purposes not listed in this medication guide.
IMPORTANT INFORMATION
Do not use clomiphene if you are already pregnant.
You should not use clomiphene if you have: liver disease, abnormal vaginal bleeding, an uncontrolled adrenal gland or thyroid disorder, an ovarian cyst (unrelated to polycystic ovary syndrome), or if you are pregnant.
HOW TO USE CLOMIPHENE CITRATE
Use clomiphene exactly as directed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended. Your doctor will perform medical tests to make sure you do not have conditions that would prevent you from safely using clomiphene. Clomiphene is usually taken for 5 days, starting on the 5th day of your menstrual period. Follow your doctor’s instructions.
You will need to have a pelvic examination before each treatment cycle. You must remain under the care of a doctor while you are using this medicine. You will most likely ovulate within 5 to 10 days after you take clomiphene. To improve your chance of becoming pregnant, you should have sexual intercourse while you are ovulating. Your doctor may have you take your temperature each morning and record your daily readings on a chart. This will help you determine when you can expect ovulation to occur.
In most cases, clomiphene should not be used for more than 3 treatment cycles. If ovulation occurs but you do not get pregnant after 3 treatment cycles, your doctor may stop treatment and evaluate your infertility further. Store at room temperature away from moisture, heat, and light.
CLOMIPHENE CITRATE DOSING INFORMATION
Usual Adult Dose for Ovulation Induction: 50 mg orally once a day for 5 days. Therapy should be initiated on or near the 5th day of the menstrual cycle, but may be started at any time in patients without recent uterine bleeding.
Usual Adult Dose for Lactation Suppression: 50 to 100 mg orally once a day for 5 days. Generally, one course of therapy is sufficient.
Usual Adult Dose for Oligospermia: 25 to 100 mg orally once a day. Therapy is generally given over a period of several months.
CLOMIPHENE CITRATE SIDE EFFECTS
Get emergency medical help if you have any signs of an allergic reaction to clomiphene: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Some women using this medicine develop a condition called ovarian hyperstimulation syndrome (OHSS), especially after the first treatment. OHSS can be a life threatening condition. Call your doctor right away if you have any of the following symptoms of OHSS:
• stomach pain, bloating;
• nausea, vomiting, diarrhea;
• rapid weight gain, especially in your face and midsection;
• little or no urinating; or
• pain when you breathe, rapid heart rate, feeling short of breath (especially when lying down).
Stop using clomiphene and call your doctor at once if you have:
• pelvic pain or pressure, enlargement in your pelvic area;
• vision problems;
• seeing flashes of light or “floaters” in your vision;
• increased sensitivity of your eyes to light; or
• heavy vaginal bleeding.
Common clomiphene side effects may include:
• flushing (warmth, redness, or tingly feeling);
• breast pain or tenderness;
• headache; or
• breakthrough bleeding or spotting.
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